The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]‐(+)‐propyl‐hexahydro‐naphtho‐oxazin and [11C]raclopride
Identifieur interne : 000F22 ( Main/Exploration ); précédent : 000F21; suivant : 000F23The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]‐(+)‐propyl‐hexahydro‐naphtho‐oxazin and [11C]raclopride
Auteurs : Isabelle Boileau [Canada, Niger] ; Doris Payer [Canada] ; Bindiya Chugani [Canada] ; Daniela Lobo [Canada] ; Arian Behzadi [Canada] ; Pablo M. Rusjan [Canada] ; Sylvain Houle [Canada] ; Alan A. Wilson [Canada] ; Jerry Warsh [Canada] ; Stephen J. Kish [Canada] ; Martin Zack [Canada]Source :
- Addiction [ 0965-2140 ] ; 2013-05.
Abstract
Pathological gambling (PG) shares diagnostic features with substance use disorder (SUD), but the neurochemical mechanisms underlying PG are poorly understood. Because dopamine (DA), a neurotransmitter implicated in reward and reinforcement, is probably involved, we used positron emission tomography (PET) to test whether PG is associated with abnormalities in D2 and D3 receptor levels, as observed in SUD.
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DOI: 10.1111/add.12066
Affiliations:
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Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Warsh, Jerry" sort="Warsh, Jerry" uniqKey="Warsh J" first="Jerry" last="Warsh">Jerry Warsh</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Neuroscience Program, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, University of Toronto, ON, Toronto</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Vivian M. Rakoff PET Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Human Brain Laboratory, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Zack, Martin" sort="Zack, Martin" uniqKey="Zack M" first="Martin" last="Zack">Martin Zack</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Neuroscience Program, Centre for Addiction and Mental Health, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacology, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Public Health Sciences, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Addiction</title><title level="j" type="abbrev">Addiction</title><idno type="ISSN">0965-2140</idno><idno type="eISSN">1360-0443</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-05">2013-05</date><biblScope unit="volume">108</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="953">953</biblScope><biblScope unit="page" to="963">963</biblScope></imprint><idno type="ISSN">0965-2140</idno></series><idno type="istex">AD3295315D5BAF823520ED673AAC9F99814B6F4B</idno><idno type="DOI">10.1111/add.12066</idno><idno type="ArticleID">ADD12066</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0965-2140</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Pathological gambling (PG) shares diagnostic features with substance use disorder (SUD), but the neurochemical mechanisms underlying PG are poorly understood. Because dopamine (DA), a neurotransmitter implicated in reward and reinforcement, is probably involved, we used positron emission tomography (PET) to test whether PG is associated with abnormalities in D2 and D3 receptor levels, as observed in SUD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Niger</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name></noRegion><name sortKey="Behzadi, Arian" sort="Behzadi, Arian" uniqKey="Behzadi A" first="Arian" last="Behzadi">Arian Behzadi</name><name sortKey="Behzadi, Arian" sort="Behzadi, Arian" uniqKey="Behzadi A" first="Arian" last="Behzadi">Arian Behzadi</name><name sortKey="Behzadi, Arian" sort="Behzadi, Arian" uniqKey="Behzadi A" first="Arian" last="Behzadi">Arian Behzadi</name><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name><name sortKey="Chugani, Bindiya" sort="Chugani, Bindiya" uniqKey="Chugani B" first="Bindiya" last="Chugani">Bindiya Chugani</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J." last="Kish">Stephen J. Kish</name><name sortKey="Lobo, Daniela" sort="Lobo, Daniela" uniqKey="Lobo D" first="Daniela" last="Lobo">Daniela Lobo</name><name sortKey="Lobo, Daniela" sort="Lobo, Daniela" uniqKey="Lobo D" first="Daniela" last="Lobo">Daniela Lobo</name><name sortKey="Lobo, Daniela" sort="Lobo, Daniela" uniqKey="Lobo D" first="Daniela" last="Lobo">Daniela Lobo</name><name sortKey="Payer, Doris" sort="Payer, Doris" uniqKey="Payer D" first="Doris" last="Payer">Doris Payer</name><name sortKey="Payer, Doris" sort="Payer, Doris" uniqKey="Payer D" first="Doris" last="Payer">Doris Payer</name><name sortKey="Payer, Doris" sort="Payer, Doris" uniqKey="Payer D" first="Doris" last="Payer">Doris Payer</name><name sortKey="Rusjan, Pablo M" sort="Rusjan, Pablo M" uniqKey="Rusjan P" first="Pablo M." last="Rusjan">Pablo M. Rusjan</name><name sortKey="Warsh, Jerry" sort="Warsh, Jerry" uniqKey="Warsh J" first="Jerry" last="Warsh">Jerry Warsh</name><name sortKey="Warsh, Jerry" sort="Warsh, Jerry" uniqKey="Warsh J" first="Jerry" last="Warsh">Jerry Warsh</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A." last="Wilson">Alan A. Wilson</name><name sortKey="Zack, Martin" sort="Zack, Martin" uniqKey="Zack M" first="Martin" last="Zack">Martin Zack</name><name sortKey="Zack, Martin" sort="Zack, Martin" uniqKey="Zack M" first="Martin" last="Zack">Martin Zack</name><name sortKey="Zack, Martin" sort="Zack, Martin" uniqKey="Zack M" first="Martin" last="Zack">Martin Zack</name></country><country name="Niger"><noRegion><name sortKey="Boileau, Isabelle" sort="Boileau, Isabelle" uniqKey="Boileau I" first="Isabelle" last="Boileau">Isabelle Boileau</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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